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RNA IN PRESS

Melissa L. Wells, Stephanie N. Hicks, Lalith Perera, Perry J. Blackshear
First Published on Aug 19, 2015
Qing Ye, Meng Wang, Zhi-Peng Fang, Zhi-Rong Ruan, Quan-Quan Ji, Xiao-Long Zhou, En-Duo Wang
First Published on Aug 13, 2015
Alexandra C. Title, Remy Denzler, Markus Stoffel
First Published on Aug 03, 2015
Enrico Caserta, Liang-Chun Liu, Frank J. Grundy, Tina M. Henkin
First Published on Jul 30, 2015
Jacob M. Vogan, Kathleen Collins
First Published on Jul 13, 2015

Best of 2014

Satoshi Ito, Yu Akamatsu, Akiko Noma, Satoshi Kimura, Kenjyo Miyauchi, Yoshiho Ikeuchi, Takeo Suzuki, Tsutomu Suzuki
September 19, 2014 The Journal of Biological Chemistry, 289, 26201-26212.

PAPERS OF THE WEEK

Rpb2-Rpb4 fusion yeast mutant rescues synthesis and degradation defects of 
yeast bearing the Rpb4 deletion.
First Published on Jun 20, 2014
Ribbon drawing of the tertiary structure of /T. thermophiles/ SmpB. The side 
chains of residues analyzed in this study are shown in a ball-and-stick 
representation. The tmRNA binding surface of SmpB is also indicated.
First Published on Oct 18, 2013
Hypothetical model describing the roles of eIF1 and eIF1A in start codon 
recognition.
First Published on Sep 20, 2013
Ribosome degradation during growth of /E. coli/ in media with or without 
arsenic.
First Published on Aug 17, 2012
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REPORTS

Satoshi Ito, Sayuri Horikawa, Tateki Suzuki, Hiroki Kawauchi, Yoshikazu Tanaka, Takeo Suzuki, Tsutomu Suzuki
First Published on Nov 19, 2014

CLASSICS

E. Peter Geiduschek
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Dec 24, 2010
Roger D. Kornberg
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 16, 2009
Har Gobind Khorana
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on May 22, 2009
Dieter Söll
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jun 22, 2007
A youthful Leon Heppel. Courtesy of the Office of NIH History, National 
Institutes of Health and Dr. Buhm Soon Park.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 27, 2007
Masayasu Nomura
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Mar 30, 2007
Sidney Altman
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Feb 09, 2007
Michael J. Chamberlin. Photo courtesy of /Sigma Xi Today/.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Nov 03, 2006
Peter Reichard. Photo reprinted with permission from the /Annual Review of 
Biochemistry/, Vol. 64. ©1995 by Annual Reviews (www.annualreviews.org).
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 14, 2006
Jerard Hurwitz. Photograph courtesy of the Memorial Sloan-Kettering Cancer 
Center.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 07, 2006
Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Feb 10, 2006
The sequence of amino acid residues in oxidized bovine ribonuclease. This 
figure was taken from the first JBC Classic reprinted here.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Dec 09, 2005
/a/, Mahlon Hoagland, Paul Zamecnik, and Mary Stephenson. /b/, same 
characters, approximately 35 years later. Reprinted with permission from the 
/Annual Review of Biochemistry/, Vol. 74. © 2005 by Annual Reviews, 
www.annualreviews.org.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 30, 2005
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REFLECTIONS

*The author in his laboratory at UCSC as an assistant professor in 1970.*
Harry F. Noller
First Published on Jun 27, 2013
*James E. Darnell, Jr.*
James E. Darnell Jr.
First Published on Mar 22, 2013
*R. G. (/right/) at MIT with Alex Rich (/left/) and Tom RajBhandary 
(/middle/) on the occasion of Alex's eightieth birthday party (June 10, 
2005).*
Richard Giegé
First Published on Jan 16, 2013
*From left: George Rathmann, Robert Letsinger, and H. Gobind Khorana.*
Marvin H. Caruthers
First Published on Dec 07, 2012
*Jerry Hurwitz (2006) at the Memorial Sloan-Kettering Cancer Center.*
Lucy Shapiro
First Published on Sep 24, 2012
*Adrift in 1970.*
Christine Guthrie
First Published on Oct 30, 2009
*Intron-containing /td/ gene and activity of its products.* /A/, the /td/ 
gene, intron RNA, and protein products. For /DNA/, the /td/ intron (/red/) 
interrupts the exons encoding TS (/yellow/). For /RNA/, shown is the 
secondary structure, with the intron open reading frame (/ORF/) encoding 
endonuclease I-TevI looped out of element P6. The circular spliced intron and 
ligated TS exons are shown below. For /PROTEIN/, TS, the product of ligated 
exons, and I-TevI, the intron endonuclease, are shown. /B/, group I intron 
splicing pathway. The /td/ intron splices by guanosine attack (/G-OH/) on the 
5′-splice site (/step 1/). Transesterification by the 3′-OH of the 
upstream exon results in ligated exons and a free intron (/step 2/), which 
cyclizes (/step 3/). /C/, homing of the /td/ intron. I-TevI (/dumbbell/), 
encoded by the intron (/step 1/), cleaves the recipient homing site (/step 
2/), and after resection of the cleaved DNA (/step 3/), synapsis occurs 
(/step 4/). DSBR or SDSA, followed by repair, yields homing products (/step 
5/).
Marlene Belfort
First Published on Aug 26, 2009
*General schematic representation of the elongation cycle of a translating 
ribosome.* Each cycle results in (i) elongation of a growing peptide chain by 
one amino acid residue (formation of one peptide bond), (ii) hydrolysis of 
two GTP molecules, (iii) entry of one molecule of aminoacyl (/Aa/)-tRNA into 
intersubunit channel, (iv) exit of one molecule of deacylated tRNA from the 
intersubunit channel, and (v) movement of mRNA chain by three nucleotides 
toward the 3′-end. Here, as well as in Figs. 3–5, ribosomal particles are 
shown in the orientation in which the small subunit (/yellow/) is on the top 
and the large subunit (/red/) is on the bottom. The head of the small subunit 
and the central protuberance of the large subunit are facing the viewer, with 
the L7/L12 stalk of the large subunit directed to the left. In this 
orientation, the bound L-like tRNAs must face the viewer by their external 
angles (“elbows”), as in reality they are facing the head of the small 
subunit; however, here, as well as in Figs. 3–5, for the sake of better 
discerning between the A and P site tRNAs, the external angles of their 
symbolical depictions (/green/) are shown to be drawn apart. The intersubunit 
channel accommodating the mRNA and tRNAs is traced by /dotted lines/. A and P 
are the tRNA-binding sites on the small subunit, and /a/, /p/, and /e/ are 
the binding sites for their 3′ termini, either acylated or deacylated, on 
the large subunit. (For the sake of better clarity, the subsites on the small 
subunit are designated by capital letters, A and P, as originally proposed 
and usually accepted (59, 94), whereas the large subunit subsites, which are 
localized within a small area of the PTC and nearby, are designated by 
lowercase italicized letters, /a/ and /p/, as proposed elsewhere (92).)
Alexander S. Spirin
First Published on May 05, 2009
The thiazolium ion loses a proton at C-2 to form a zwitterion that has a 
carbene resonance form. This resonance hybrid species is the catalytic form 
in biochemical reactions catalyzed by thiamine diphosphate.
Ronald Breslow
First Published on Sep 10, 2008
*Flow of genetic information from DNA to the tRNA-mRNA on the ribosome.*
Paul Schimmel
First Published on Jul 18, 2008
Photo credit: Massachusetts Institute of Technology/Donna Coveney.
Alexander Rich
First Published on Mar 17, 2006
Photo courtesy of the Sloan-Kettering Memorial Cancer Center.
Jerard Hurwitz
First Published on Oct 17, 2005
*A youthful Leon Heppel.* Courtesy of the Office of NIH History, National 
Institutes of Health and Dr. Buhm Soon Park.
Maxine Singer
First Published on Sep 15, 2003
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MINIREVIEWS

William C. Merrick
First Published on Aug 31, 2015
Henrik G. Dohlman
First Published on Jan 20, 2015

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Lisa B. Frankel, Nanna R. Christoffersen, Anders Jacobsen, Morten Lindow, Anders Krogh, Anders H. Lund
First Published on Nov 08, 2007
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